Blood-based epigenome-wide analyses of cognitive abilities

被引：15

作者：

McCartney, Daniel L. ^{[1
]}

Hillary, Robert F. ^{[1
]}

Conole, Eleanor L. S. ^{[2
,3
]}

Banos, Daniel Trejo ^{[4
,5
]}

Gadd, Danni A. ^{[1
]}

Walker, Rosie M. ^{[1
,3
]}

Nangle, Cliff ^{[1
]}

Flaig, Robin ^{[1
]}

Campbell, Archie ^{[1
]}

Murray, Alison D. ^{[6
]}

Maniega, Susana Munoz ^{[2
,3
]}

Valdes-Hernandez, Maria Del C. ^{[2
,3
]}

Harris, Mathew A. ^{[2
]}

Bastin, Mark E. ^{[2
,3
]}

Wardlaw, Joanna M. ^{[2
,3
]}

Harris, Sarah E. ^{[2
]}

Porteous, David J. ^{[1
]}

Tucker-Drob, Elliot M. ^{[7
,8
,9
]}

McIntosh, Andrew M. ^{[1
,10
]}

Evans, Kathryn L. ^{[1
]}

Deary, Ian J. ^{[2
]}

Cox, Simon R. ^{[2
]}

Robinson, Matthew R. ^{[11
]}

Marioni, Riccardo E. ^{[1
]}

机构：

[1] Univ Edinburgh, Ctr Genom & Expt Med, Inst Genet & Canc, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Dept Psychol, Lothian Birth Cohorts, Edinburgh EH8 9JZ, Midlothian, Scotland

[3] Univ Edinburgh, Ctr Clin Brain Sci, UK Dementia Res Inst, Chancellors Bldg,49 Little France Crescent, Edinburgh EH16 4SB, Midlothian, Scotland

[4] Univ Zurich, Dept Quantitat Biomed, Zurich, Switzerland

[5] Univ Hosp Zurich, Biomed Informat, Zurich, Switzerland

[6] Univ Aberdeen, Aberdeen Biomed Imaging Ctr, Aberdeen, Scotland

[7] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[8] Univ Texas Austin, Populat Res Ctr, Austin, TX 78712 USA

[9] Univ Texas Austin, Ctr Aging & Populat Sci, Austin, TX 78712 USA

[10] Univ Edinburgh, Ctr Clin Brain Sci, Div Psychiat, Edinburgh, Midlothian, Scotland

[11] IST Austria, A-3400 Klosterneuburg, Austria

来源：

GENOME BIOLOGY | 2022年 / 23卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

DNA methylation; EWAS; Cognitive ability; Prediction; Epidemiology; LOTHIAN BIRTH COHORT; TRACTOGRAPHY; DISEASE;

D O I：

10.1186/s13059-021-02596-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. Results: Using blood-based epigenome-wide analyses of general cognitive function, we show that individual differences in DNA methylation (DNAm) explain 35.0% of the variance in general cognitive function (g). A DNAm predictor explains similar to 4% of the variance, independently of a polygenic score, in two external cohorts. It also associates with circulating levels of neurology- and inflammation-related proteins, global brain imaging metrics, and regional cortical volumes. Conclusions: As sample sizes increase, the ability to assess cognitive function from DNAm data may be informative in settings where cognitive testing is unreliable or unavailable.

引用

页数：16

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