Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics

被引：102
|
作者：
Li, Kai [1 ]
Nejadnik, Hossein
Daldrup-Link, Heike E. [1 ]
机构：
[1] Stanford Sch Med, Dept Radiol, Stanford, CA 94305 USA
来源：
DRUG DISCOVERY TODAY | 2017年 / 22卷 / 09期
关键词：
PHOTODYNAMIC THERAPY; DRUG-DELIVERY; BREAST-CANCER; POLYPYRROLE NANOPARTICLES; MAGNETIC NANOPARTICLES; PHOTOTHERMAL THERAPY; OPEN-LABEL; MRI; CHEMOTHERAPY; COMBINATION;
D O I：
10.1016/j.drudis.2017.04.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI. First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices. This review provides an overview of recently developed polymer-coated multifunctional SPIO nanoparticles for cancer theranostics and discusses current challenges and future perspectives.
引用
收藏
页码：1421 / 1429
页数：9
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