One-pot multicomponent diastereoselective synthesis of novel dihydro-1H-furo[2,3-c]pyrazoles

被引：8
|
作者：
Tangeti, Venkata Swamy [1 ]
Prasad, G. V. Siva [1 ]
Panda, Jagadeesh [2 ]
Varma, K. Ramesh [3 ]
机构：
[1] Raghu Engn Coll, Vishakhapatnam, India
[2] Raghu Coll Pharm, Vishakhapatnam, India
[3] Sri Venkateswara Univ, Tirupati, India
来源：
SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 10期
关键词：
Dihydrofuro[1,2-b]pyrazole; microwave synthesis; multicomponent; solvent free; 3-COMPONENT SYNTHESIS; ORGANIC-SYNTHESIS; CHEMISTRY; DRUGS;
D O I：
10.1080/00397911.2016.1174781
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method was developed for the diastereoselective synthesis of novel fused dihydro-1H-furo[2,3-c]pyrazole by a one-pot, four-component reaction of beta-keto ester, hydrazine, aromatic aldehyde, and pyridinium ylide in the presence of triethylamine under microwave irradiation in solvent-free conditions in good yields. The merits of this cascade Knoevenagel condensation/Michael addition/cyclization sequence include its high atom economy, good yields, and efficiency of producing three new bonds (two C-C and one C-O) and two stereocenters in a single operation.
引用
收藏
页码：878 / 884
页数：7
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