Methanol Promoted Palladium-Catalyzed Amine Formylation with CO2 and H2 by the Formation of HCOOCH3

The N-formylation reaction of amines is one of the most effective measures to make the best use of CO2, since the formamides have widespread applications in industry. Herein, we performed the N-formylation reaction over Mg-Al layered double hydroxide (Mg-Al LDH) supported Pd catalyst (Pd/LDH) for the first time and studied the relation between the solvent and the mechanism. In this reaction, the methanol can greatly improve the yield of the desired product by forming the HCOOCH3. The catalytic system is effective for various amines including cyclic and alkyl secondary amines. Under the optimized reaction condition, we gained 88.5 %-97.4 % yields of the formamides for various substrates.