Longitudinal Brain Atrophy Rates in Transient Ischemic Attack and Minor Ischemic Stroke Patients and Cognitive Profiles

被引：13

作者：

Munir, Muhammad ^{[1
,2
]}

Ursenbach, Jake ^{[1
,2
]}

Reid, Meaghan ^{[1
,2
]}

Sah, Rani Gupta ^{[1
,2
,3
,4
]}

Wang, Meng ^{[5
]}

Sitaram, Amith ^{[1
,2
,4
]}

Aftab, Arooj ^{[1
]}

Tariq, Sana ^{[1
,2
]}

Zamboni, Giovanna ^{[6
]}

Griffanti, Ludovica ^{[6
]}

Smith, Eric E. ^{[1
,4
]}

Frayne, Richard ^{[2
,3
,4
]}

Sajobi, Tolulope T. ^{[1
,5
]}

Coutts, Shelagh B. ^{[1
,2
,4
]}

d'Esterre, Christopher D. ^{[1
,2
]}

Barber, Philip A. ^{[1
,3
,4
,5
]}

Weiner, Michael W. ^{[7
,9
]}

Aisen, Paul ^{[8
]}

Weiner, Michael ^{[9
,92
]}

Petersen, Ronald ^{[10
]}

Jack, Clifford R., Jr. ^{[10
]}

Jagust, William ^{[7
,11
]}

Trojanowki, John Q. ^{[12
,37
,94
]}

Toga, Arthur W. ^{[8
,13
]}

Beckett, Laurel ^{[14
]}

Green, Robert C. ^{[15
,91
]}

Saykin, Andrew J. ^{[16
]}

Morris, John ^{[17
]}

Shaw, Leslie M. ^{[12
,37
,94
]}

Khachaturian, Zaven ^{[18
]}

Sorensen, Greg ^{[19
]}

Carrillo, Maria ^{[20
]}

Kuller, Lew ^{[21
]}

Raichle, Marc ^{[17
]}

Paul, Steven ^{[22
]}

Davies, Peter ^{[23
]}

Fillit, Howard ^{[24
]}

Hefti, Franz ^{[25
]}

Holtzman, David ^{[17
,26
]}

Mesulam, M. Marcel ^{[26
]}

Potter, William ^{[27
]}

Snyder, Peter ^{[28
]}

Montine, Tom ^{[29
]}

Jimenez, Gustavo ^{[13
]}

Donohue, Michael ^{[13
,30
]}

Gessert, Devon ^{[13
]}

Harless, Kelly ^{[13
]}

Salazar, Jennifer ^{[13
]}

Cabrera, Yuliana ^{[13
]}

Walter, Sarah ^{[13
]}

机构：

[1] Foothills Med Ctr, Dept Clin Neurosci, Calgary Stroke Program, Calgary, AB, Canada

[2] Foothills Med Ctr, Seaman Family MR Ctr, Calgary, AB, Canada

[3] Foothills Med Ctr, Dept Radiol, Calgary, AB, Canada

[4] Univ Calgary, Cumming Sch Med, Hotchkiss Brain Inst, Calgary, AB, Canada

[5] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada

[6] Univ Oxford, John Radcliffe Hosp, FMRIB Ctr, Oxford, England

[7] Univ Calif San Francisco, San Francisco, CA 94143 USA

[8] Univ Southern Calif, Los Angeles, CA USA

[9] UC San Francisco, San Francisco, CA USA

[10] Mayo Clin, Rochester, MN USA

[11] Univ Calif Berkeley, Berkeley, CA USA

[12] Univ Penn, Philadelphia, PA 19104 USA

[13] USC, Los Angeles, CA USA

[14] Univ Calif Davis, Davis, CA USA

[15] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA

[16] Indiana Univ, Bloomington, IN 47405 USA

[17] Washington Univ, St Louis, MO USA

[18] Prevent Alzheimers Dis 2020, Rockville, MD USA

[19] Siemens AG, Washington, DC USA

[20] Alzheimers Assoc, Chicago, IL USA

[21] Univ Pittsburgh, Pittsburgh, PA 15260 USA

[22] Cornell Univ, Ithaca, NY 14853 USA

[23] Yeshiva Univ, Albert Einstein Coll Med, New York, NY 10033 USA

[24] AD Drug Discovery Fdn, New York, NY USA

[25] Acumen Pharmaceut, Livermore, CA USA

[26] Northwestern Univ, Evanston, IL 60208 USA

[27] NIMH, Bethesda, MD 20892 USA

[28] Brown Univ, Providence, RI 02912 USA

[29] Univ Washington, Seattle, WA 98195 USA

[30] Univ Calif San Diego, San Diego, CA USA

[31] Univ London, London, England

[32] UCLA, Sch Med, Los Angeles, CA USA

[33] UCSF, MRI, San Francisco, CA USA

[34] Univ Michigan, Ann Arbor, MI 48109 USA

[35] Univ Utah, Salt Lake City, UT 84112 USA

[36] Banner Alzheimers Inst, Phoenix, AZ USA

[37] UPenn Sch Med, Philadelphia, PA USA

[38] UC Irvine, Irvine, CA USA

[39] NIA, Bethesda, MD 20892 USA

[40] Johns Hopkins Univ, Baltimore, MD 21218 USA

[41] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[42] Univ Calif San Diego, La Jolla, CA 92093 USA

[43] Baylor Coll Med, Houston, TX 77030 USA

[44] Columbia Univ, Med Ctr, New York, NY 10027 USA

[45] Univ Alabama Birmingham, Birmingham, AL USA

[46] Mt Sinai Sch Med, New York, NY USA

[47] Rush Univ, Med Ctr, Chicago, IL USA

[48] Wien Ctr, New York, NY USA

[49] NYU, New York, NY 10003 USA

[50] Duke Univ, Med Ctr, Durham, NC 27706 USA

来源：

FRONTIERS IN NEUROLOGY | 2019年 / 10卷

基金：

美国国家卫生研究院;

关键词：

brain; transient ischemic attack; stroke; cognition battery; atrophy rates; diffusion weighted imaging; white matter lesion; longitudinal; MEDIAL TEMPORAL ATROPHY; SMALL VESSEL DISEASE; ALZHEIMERS-DISEASE; MRI; IMPAIRMENT; DECLINE; VOLUME; PERFORMANCE; DEMENTIA; SCANNERS;

D O I：

10.3389/fneur.2019.00018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Patients with transient ischemic attack (TIA) and minor stroke demonstrate cognitive impairment, and a four-fold risk of late-life dementia. Aim: To study the extent to which the rates of brain volume loss in TIA patients differ from healthy controls and how they are correlated with cognitive impairment. Methods: TIA or minor stroke patients were tested with a neuropsychological battery and underwent T1 weighted volumetric magnetic resonance imaging scans at fixed intervals over a 3 years period. Linear mixed effects regression models were used to compare brain atrophy rates between groups, and to determine the relationship between atrophy rates and cognitive function in TIA and minor stroke patients. Results: Whole brain atrophy rates were calculated for the TIA and minor stroke patients; n = 38 between 24 h and 18 months, and n = 68 participants between 18 and 36 months, and were compared to healthy controls. TIA and minor stroke patients demonstrated a significantly higher whole brain atrophy rate than healthy controls over a 3 years interval (p = 0.043). Diabetes (p = 0.012) independently predicted higher atrophy rate across groups. There was a relationship between higher rates of brain atrophy and processing speed (composite P = 0.047 and digit symbol coding P = 0.02), but there was no relationship with brain atrophy rates and memory or executive composite scores or individual cognitive tests for language (Boston naming, memory recall, verbal fluency or Trails A or B score). Conclusion: TIA and minor stroke patients experience a significantly higher rate of whole brain atrophy. In this cohort of TIA and minor stroke patients changes in brain volume over time precede cognitive decline.

引用

页数：9

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