First-row transition metal catalyzed reduction of carbonyl functionalities: a mechanistic perspective

The use of first-row transition metals lot the catalytic reduction of carbonyl functionalities has become increasingly important in homogeneous catalysis This Perspective examines the mechanistic aspects of these reduction reactions, with a focus on various interactions between metal complexes and substrates Four different types of catalytic pathways. namely catalysis with dihydride (or dihydrogen) complexes. catalysis with monohydride complexes. metal-ligand bifunctional catalysis. and catalysis involving ionic mechanisms, are discussed with recent examples highlighted