Oxidative Cleavage of Silyl Ethers by an Oxoammonium Salt

被引：8
|
作者：
Loman, Jacob J. [1 ]
Pistritto, Vincent A. [1 ]
Kelly, Christopher B. [1 ]
Leadbeater, Nicholas E. [1 ,2 ]
机构：
[1] Univ Connecticut, Dept Chem, 55 North Eagleville Rd, Storrs, CT 06269 USA
[2] Univ Connecticut, Ctr Hlth, Dept Community Med & Hlth Care, 263 Farmington Ave, Farmington, CT 06030 USA
来源：
SYNLETT | 2016年 / 27卷 / 16期
基金：
美国国家科学基金会;
关键词：
protecting groups; silicon; oxidation; oxoammonium salt; aldehydes; ketones; DEPROTECTION; COMPLEXES; ALCOHOLS; TEMPO;
D O I：
10.1055/s-0035-1561498
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the oxidative cleavage of silyl ethers to their corresponding carbonyl species mediated by an oxoammonium salt is described. The resulting aldehydes and ketones are obtained under mild reaction conditions with no observed overoxidation. For robust substrates, heating to reflux temperatures significantly reduces the reaction time.
引用
收藏
页码：2372 / 2377
页数：6
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