A pulse radiolysis study of an imidazolato-bridged asymmetric dicopper(II) complex:: A structural and functional mimic of superoxide dismutase

被引：0
|
作者：
Tabbì, G
Nauser, T
Koppenol, WH
Reedijk, J
机构：
[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
[2] ETH Zentrum, Anorgan Chem Lab, CH-8092 Zurich, Switzerland
[3] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 1998年 / 12期
关键词：
superoxide dismutase mimic; pulse radiolysis; imidazolato-bridged dicopper(II) complex; copper; radicals;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The ability of a dicopper(II) complex with a pentadentate, imidazolato-bridged ligand having two different coordination environments to mimic the reactivity of superoxide dismutase has been investigated by pulse radiolysis. Pseudo first-order kinetics were observed for superoxide scavenging, with a very high rate constant of 1.9 +/- 0.4 x 10(9) M-1 s(-1), consistent with catalytic dismutation of superoxide by the complex. This value is essentially constant over the pH range of 5 to 7, and agrees with earlier results obtained with the nitroblue tetrazolium assay.
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页码：1939 / 1943
页数：5
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