Eosinophilic Chronic Obstructive Pulmonary Disease

被引：11
|
作者：
Weissler, Jonathan C. [1 ]
Adams, Traci N. [1 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Div Pulm & Crit Care Med, Dept Internal Med, 6201 Harry Hines Blvd, Dallas, TX 75390 USA
来源：
LUNG | 2021年 / 199卷 / 06期
关键词：
Eosinophilia; COPD; Exacerbation; Interleukin-5; Corticosteroid; BLOOD EOSINOPHILS; INHALED CORTICOSTEROIDS; PERSISTENT ASTHMA; DOUBLE-BLIND; SECONDARY ANALYSIS; EPITHELIAL-CELLS; MEPOLIZUMAB; SPUTUM; EFFICACY; COPD;
D O I：
10.1007/s00408-021-00492-0
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Recent therapeutic advances in the management of asthma have underscored the importance of eosinophilia and the role of pro-eosinophilic mediators such as IL-5 in asthma. Given that a subset of patients with COPD may display peripheral eosinophilia similar to what is observed in asthma, a number of recent studies have implied that eosinophilic COPD is a distinct entity. This review will seek to contrast the mechanisms of eosinophilia in asthma and COPD, the implications of eosinophilia for disease outcome, and review current data regarding the utility of peripheral blood eosinophilia in the management of COPD patients.
引用
收藏
页码：589 / 595
页数：7
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