Molecular dynamic simulation of the thermodynamic and kinetic properties of nucleotide base pair

被引：5
|
作者：
Wang, Yu-Jie [1 ,2 ]
Wang, Zhen [1 ]
Wang, Yan-Li [1 ]
Zhang, Wen-Bing [1 ]
机构：
[1] Wuhan Univ, Dept Phys, Wuhan 430071, Hubei, Peoples R China
[2] Zhoukou Normal Univ, Dept Phys & Telecommun Engn, Zhoukou 466000, Peoples R China
来源：
CHINESE PHYSICS B | 2017年 / 26卷 / 12期
基金：
中国国家自然科学基金;
关键词：
thermodynamics; kinetics; molecular dynamic simulation; IMINO PROTON-EXCHANGE; REAL-TIME NMR; SEQUENCE-DEPENDENCE; REFOLDING KINETICS; FOLDING LANDSCAPE; RNA STRUCTURE; FREE-ENERGY; B-DNA; PATHWAYS; FLUCTUATIONS;
D O I：
10.1088/1674-1056/26/12/128705
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
A nucleotide base pair is the basic unit of RNA structures. Understanding the thermodynamic and kinetic properties of the closing and opening of a base pair is vital for quantitative understanding the biological functions of many RNA molecules. Due to the fast transition rate, it is difficult to directly observe opening and closing of single nucleic acid base pair in experiments. This review will provide a brief summary of the studies about the thermodynamic and kinetic properties of a base pair opening and closing by using molecular dynamic simulation methods.
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页数：6
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