NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: synthesis of dihetaryl substituted alkenes

被引：6

作者：

Zhang, Chen ^{[1
]}

Shi, Yu-Long ^{[1
]}

Zhang, Li-Yu ^{[1
]}

Yuan, Dong-Peng ^{[2
]}

Ban, Meng-Tao ^{[1
]}

Zheng, Jia-Yao ^{[1
]}

Liu, Deng-Hui ^{[1
]}

Guo, Shun-Na ^{[1
]}

Cui, Dong-Mei ^{[2
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2018年 / 42卷 / 21期

关键词：

CROSS-COUPLING REACTIONS; RUTHENIUM-CATALYZED SYNTHESIS; ULLMANN-TYPE REACTION; VINYL BROMIDES; 1,1-DIBROMO-1-ALKENES; IMIDAZOLES; PHENOLS; LIGANDS; HALIDES; NUCLEOPHILES;

D O I：

10.1039/c8nj02756k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1H-azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1,1-dihaloalkenes containing functionalities such as nitriles, ethers, and halogens. Imidazoles and triazoles also afforded the desired products.

引用

页码：17732 / 17739

页数：8

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