Green Decarboxylative Aminoalkylation of Coumarin-3-Carboxylic Acids

被引：4

作者：

Soltani, Siavash Salek ^{[1
]}

Golshani, Mostafa ^{[2
]}

Moghimi, Setareh ^{[2
]}

Farnia, S. Morteza F. ^{[1
]}

Ketabforoosh, Shima H. M. E. ^{[3
]}

Akbarzadeh, Tahmineh ^{[4
]}

Foroumadi, Alireza ^{[2
,4
]}

机构：

[1] Univ Tehran, Sch Chem, Coll Sci, Tehran, Iran

[2] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Inst Pharmaceut Sci TIPS, Tehran, Iran

[3] Alborz Univ Med Sci, Dept Med Chem, Sch Pharm, Karaj, Iran

[4] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 46期

关键词：

coumarin; decarboxylation; water; green chemistry; domino reaction; additive-free; BIOLOGICAL EVALUATION; COUMARIN DERIVATIVES; CHEMISTRY; ARYLATION; STRAINS;

D O I：

10.1002/slct.201902872

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new metal-free decarboxylative coupling reaction between coumarin-3-carboxylic acid derivatives, formaldehyde, and amines is developed. The use of water as the solvent without using any catalyst or additive, excellent functional group tolerance, and good yields are the beneficial features of this synthetic pathway. The cholinesterase inhibitory activity of some selected target compounds is also evaluated.

引用

页码：13695 / 13697

页数：3

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