Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression

被引：72
|
作者：
Soung, Young Hwa [1 ]
Clifford, John L. [1 ]
Chung, Jun [1 ]
机构：
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71130 USA
来源：
BMB REPORTS | 2010年 / 43卷 / 05期
关键词：
Breast carcinoma progression; Crosstalk; Growth factor receptors; Integrin; Invasion; Survival; HEPATOCYTE GROWTH-FACTOR; BETA-4; INTEGRIN; ALPHA-6-BETA-4; ALPHA-5-BETA-1; ALPHA(6)BETA(4) INTEGRIN; FIBRONECTIN RECEPTORS; ENDOTHELIAL-CELLS; ACTIVATION; PHOSPHORYLATION; MIGRATION;
D O I：
10.5483/BMBRep.2010.43.5.311
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review explored the mechanism of breast carcinoma progression by focusing on integrins and receptor tyrosine kinases (or growth factor receptors). While the primary role of integrins was previously thought to be solely as mediators of adhesive interactions between cells and extracellular matrices, it is now believed that integrins also regulate signaling pathways that control cancer cell growth, survival, and invasion. A large body of evidence suggests that the cooperation between integrin and receptor tyrosine kinase signaling regulates certain signaling functions that are important for cancer progression. Recent developments on the crosstalk between integrins and receptor tyrosine kinases, and its implication in mammary tumor progression, are discussed. [BMB reports 2010; 43(5): 311-318]
引用
收藏
页码：311 / 318
页数：8
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