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- [2] This question was just on the Penn Hypothermia Web site: when should hypothermia be terminated during the TH process once it has begun? What criteria, if any, do you use? Once started, do you use your exclusion criteria? For example, if your patient becomes hemodynamically unstable and you are unable to maintain the MAP at the target despite fluids and pressors, do you stop cooling and start rewarming? [J]. THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT, 2011, 1 (04) : 221 - 222