Clozapine antagonizes the induction of striatal Fos expression by typical neuroleptics

被引：8
|
作者：
Wirtshafter, D [1 ]
机构：
[1] Univ Illinois, Dept Psychol, Chicago, IL 60607 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 358卷 / 03期
关键词：
atypical neuroleptic; c-Fos; striatum;
D O I：
10.1016/S0014-2999(98)00652-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Previous studies have shown that the atypical neuroleptic clozapine is less potent at inducing Fos expression in the dorsolateral striatum than are typical neuroleptics. We report here that pretreatment with clozapine (5-20 mg/kg) actually attenuates the striatal Fos expression induced by the typical neuroleptics haloperidol and raclopride. These results suggest clozapine has pharmacological properties which actively antagonize the effects of dopamine D-2 receptor blockade on-striatal immediate-early gene expression. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：R1 / R3
页数：3
相关论文
共 50 条
  • [1] Effect of typical and atypical neuroleptics on Fos protein expression in the rat forebrain
    FinkJensen, A
    Ludvigsen, TS
    Korsgaard, N
    Kristensen, P
    [J]. SCHIZOPHRENIA RESEARCH, 1996, 18 (2-3) : VIB4 - VIB4
  • [2] EFFECTS OF TYPICAL AND ATYPICAL NEUROLEPTICS ON FOS PROTEIN EXPRESSION IN THE RAT FOREBRAIN
    FINKJENSEN, A
    KRISTENSEN, P
    [J]. NEUROSCIENCE LETTERS, 1994, 182 (01) : 115 - 118
  • [3] NEUROLEPTICS INCREASE C-FOS EXPRESSION IN THE FOREBRAIN - CONTRASTING EFFECTS OF HALOPERIDOL AND CLOZAPINE
    ROBERTSON, GS
    FIBIGER, HC
    [J]. NEUROSCIENCE, 1992, 46 (02) : 315 - 328
  • [4] Clozapine withdrawal effects and receptor profiles of typical and atypical neuroleptics
    Verghese, C
    DeLeon, J
    Nair, C
    Simpson, GM
    [J]. BIOLOGICAL PSYCHIATRY, 1996, 39 (02) : 135 - 138
  • [5] NEUROLEPTICS AND STRIATAL NEUROPEPTIDE GENE-EXPRESSION
    AUGOOD, SJ
    WESTMORE, K
    FAULL, RLM
    EMSON, PC
    [J]. CHEMICAL SIGNALLING IN THE BASAL GANGLIA, 1993, 99 : 181 - 199
  • [6] POSITIVE AND NEGATIVE SYMPTOMS IN SCHIZOPHRENIA COVARY DURING TREATMENT WITH TYPICAL NEUROLEPTICS AND CLOZAPINE
    TANDON, R
    RIBEIRO, SCM
    PEREZ, M
    GOODSON, J
    GREDEN, JF
    [J]. SCHIZOPHRENIA RESEARCH, 1994, 11 (02) : 118 - 118
  • [7] STRIATAL DOPAMINE D2-RECEPTOR BLOCKADE BY TYPICAL AND ATYPICAL NEUROLEPTICS
    BRUCKE, T
    ROTH, J
    PODREKA, I
    STROBL, R
    WENGER, S
    ASENBAUM, S
    [J]. LANCET, 1992, 339 (8791): : 497 - 497
  • [8] Involvement of Adenosine A2A Receptors in the Induction of C-Fos Expression by Clozapine and Haloperidol
    Annalisa Pinna
    Jadwiga Wardas
    Alberto Cozzolino
    Micaela Morelli
    [J]. Neuropsychopharmacology, 1999, 20 : 44 - 51
  • [9] Involvement of adenosine A2A receptors in the induction of c-Fos expression by clozapine and haloperidol
    Pinna, A
    Wardas, J
    Cozzolino, A
    Morelli, M
    [J]. NEUROPSYCHOPHARMACOLOGY, 1999, 20 (01) : 44 - 51
  • [10] Changes in weight and body mass index during treatment with melperone, clozapine and typical neuroleptics
    Bobo, William V.
    Jayathilake, Karuna
    Lee, Myung A.
    Meltzer, Herbert Y.
    [J]. PSYCHIATRY RESEARCH, 2010, 176 (2-3) : 114 - 119
12345