Could smaller really be better? Current and future trends in high-resolution microcoil NMR spectroscopy

被引：40

作者：

Jones, Christopher J. ^{[1
]}

Larive, Cynthia K. ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2012年 / 402卷 / 01期

基金：

美国国家科学基金会;

关键词：

Microcoil NMR; Hyphenated techniques; Microstrip; Microslot; MAGNETIC-RESONANCE-SPECTROSCOPY; CAPILLARY-ELECTROPHORESIS; SAMPLE; H-1-NMR; PROBE; SEPARATION; ISOTACHOPHORESIS; SENSITIVITY;

D O I：

10.1007/s00216-011-5330-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

NMR is an invaluable analytical technique that provides structural and chemical information about a molecule without destroying the sample. However, NMR suffers from an inherent lack of sensitivity compared to other popular analytical techniques. This trends article focuses on strategies to increase the sensitivity of NMR using solenoidal microcoil, microstrip, and microslot probes. The role of these reduced-volume receiver coils for detection in hyphenated capillary electrophoresis (CE) and capillary isotachophoresis (cITP) NMR experiments is discussed. Future directions will likely build on work to develop probes containing multiple coils for high-throughput NMR and field-portable instruments.

引用

页码：61 / 68

页数：8

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