Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis

被引：58
|
作者：
Chan, Ho-Man [1 ]
Xiao, Lehui [1 ]
Yeung, Kai-Ming [1 ]
Ho, See-Lok [1 ]
Zhao, Dan [1 ]
Chan, Wing-Hong [1 ]
Li, Hung-Wing [1 ,2 ]
机构：
[1] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
[2] Hong Kong Baptist Univ, Ctr Surface Anal & Res, Kowloon Tong, Hong Kong, Peoples R China
来源：
BIOMATERIALS | 2012年 / 33卷 / 18期
关键词：
Nanoparticle; Self-assembly; Peptide; Surface modification; GOLD NANOPARTICLES; PROTEIN FIBRILLATION; INHIBITION; BIOLOGY; SIZE; ACID;
D O I：
10.1016/j.biomaterials.2012.03.024
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric A beta(1-40) peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis. It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the A beta(1-40) fibrillogenesis. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4443 / 4450
页数：8
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