Background: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. Hypothesis: patients given naloxegol have lower residual bladder urine volume than those given placebo. Methods: 136 patients scheduled for elective hip and knee surgery were randomized to oral naloxegol or placebo given the morning of surgery, and on the first two postoperative mornings. Residual urine volume was measured ultrasonographically within 30 min after voiding once in the morning and once in the afternoon for two postoperative days. Opioid-related Symptom Distress Scale (ORSDS), the need for indwelling urinary catheterization, and quality of recovery (QoR) score were secondary outcomes. Results: 67 were randomized to naloxegol and 64 to placebo. We did not identify a significant effect on urine residual volume, with an estimated ratio of geometric means of 0.9 (0.3, 2.6), p = 0.84. There were no significant differences in ORSDS or QoR. There were 19 (29%) patients assigned to naloxegol who needed indwelling urination catheterization versus 7 (11%) patients in the placebo group, p = 0.012. Conclusions: Our results do not support use of naloxegol for postoperative urinary retention after hip and knee surgery.
机构:
Univ Hong Kong, Med Ctr, Tung Wah Hosp, Dept Surg, Sheung Wan, Hong Kong, Peoples R ChinaUniv Hong Kong, Med Ctr, Tung Wah Hosp, Dept Surg, Sheung Wan, Hong Kong, Peoples R China
Lau, H
Lam, B
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Univ Hong Kong, Med Ctr, Tung Wah Hosp, Dept Surg, Sheung Wan, Hong Kong, Peoples R ChinaUniv Hong Kong, Med Ctr, Tung Wah Hosp, Dept Surg, Sheung Wan, Hong Kong, Peoples R China
机构:
Nanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R ChinaNanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R China
Ji, Lijiang
Wang, Aihua
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Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Rheumatol & Immunol Dept, Tianjin, Peoples R ChinaNanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R China
Wang, Aihua
Fan, Qian
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Nanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R ChinaNanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R China
Fan, Qian
Zhang, Naijin
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Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin, Peoples R ChinaNanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R China
Zhang, Naijin
Weng, Liping
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Nanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R ChinaNanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R China
Weng, Liping
Gu, Jing
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Nanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R ChinaNanjing Univ Chinese Med, Changshu Hosp, Dept Anorectal Surg, Changshu, Peoples R China