Determination of ketobemidone and its metabolites in plasma and urine using solid-phase extraction and liquid chromatography-mass spectrometry

被引：7
|
作者：
Svensson, JO [1 ]
Säwe, J [1 ]
Al-Shurbaji, A [1 ]
机构：
[1] Huddinge Univ Hosp, Div Clin Pharmacol, Dept Med Lab Sci & Technol, S-14186 Huddinge, Sweden
来源：
THERAPEUTIC DRUG MONITORING | 2001年 / 23卷 / 04期
关键词：
ketobemidone; metabolite; LC-MS;
D O I：
10.1097/00007691-200108000-00013
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The authors developed a sensitive, specific, and rapid liquid chromatography-mass spectrometry (LC-MS) method for determining ketobemidone and its major metabolites in plasma and urine. The method involves a solid-phase extraction, high-performance liquid chromatography (HPLC), and electrospray mass spectrometry. The limit of quantification for ketobemidone and norketobemidone was 3 nmol/L. Recovery rates for ketobemidone and norketobemidone were 84.8% and 81.1%, respectively. Coefficients of variation (CV) ranged from 2.8% to 9.5%. The method was used to determine ketobemidone and its major metabolites in clinical samples from relevant patient groups.
引用
收藏
页码：399 / 405
页数：7
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