Comparison of an insulin analog, insulin aspart, and regular human insulin with no insulin in gestational diabetes mellitus

被引:70
|
作者
Pettitt, DJ
Kolaczynski, JW
Ospina, P
Jovanovic, L
机构
[1] Sansum Med Res Inst, Santa Barbara, CA 93105 USA
[2] Novo Nordisk Pharmaceut Inc, Princeton, NJ USA
关键词
D O I
10.2337/diacare.26.1.183
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - To assess the short-term efficacy of insulin aspart in comparison with regular human insulin in women with gestational diabetes mellitus (GDM) during standardized meal tests. RESEARCH DESIGN AND METHODS - The study included 15 women with GDM who had inadequate diabetes control with diet alone. On 3 consecutive days, breakfast meal tests were performed-the first with no exogenous insulin and the other two after the injection of either regular insulin or insulin aspart. RESULTS - The peak insulin concentration was higher and the peak glucose and C-peptide concentrations were lower with both insulin preparations than with no exogenous insulin. Glucose areas under the curve above baseline were significantly lower with insulin aspart (180-min area, 7.1 mg . h . dl(-1); P = 0.018), but not with regular insulin (30.2 mg . h . dl(-1); P = 0.997), than with no insulin (29.4 mg . h . dl(-1)). CONCLUSIONS - This study demonstrates that effective postprandial glycemic control in women with GDM who required insulin was brought about by insulin aspart through higher insulin peak and lower demand on endogenous insulin secretion.
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页码:183 / 186
页数:4
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