Metabolic Signaling into Chromatin Modifications in the Regulation of Gene Expression

被引：21
|
作者：
Gao, Tian [1 ]
Diaz-Hirashi, Zyanya [1 ]
Verdeguer, Francisco [1 ]
机构：
[1] Univ Zurich, Dept Mol Mech Dis, CH-8057 Zurich, Switzerland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 12期
基金：
瑞士国家科学基金会;
关键词：
epigenetics; metabolic signaling; chromatin; obesity; BROWN ADIPOSE-TISSUE; HIGH-FAT DIET; ACETYL-COA; HISTONE ACETYLATION; DNA METHYLATION; S-ADENOSYLMETHIONINE; CALORIE RESTRICTION; TET ENZYMES; ACYL-COA; NAD(+);
D O I：
10.3390/ijms19124108
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The regulation of cellular metabolism is coordinated through a tissue cross-talk by hormonal control. This leads to the establishment of specific transcriptional gene programs which adapt to environmental stimuli. On the other hand, recent advances suggest that metabolic pathways could directly signal into chromatin modifications and impact on specific gene programs. The key metabolites acetyl-CoA or S-adenosyl-methionine (SAM) are examples of important metabolic hubs which play in addition a role in chromatin acetylation and methylation. In this review, we will discuss how intermediary metabolism impacts on transcription regulation and the epigenome with a particular focus in metabolic disorders.
引用
收藏
页数：15
相关论文
共 50 条
  • [1] Metabolic regulation of chromatin modifications and gene expression
    Schvartzman, Juan Manuel
    Thompson, Craig B.
    Finley, Lydia W. S.
    [J]. JOURNAL OF CELL BIOLOGY, 2018, 217 (07): : 2247 - 2259
  • [2] Chromatin -remodeling links metabolic signaling to gene expression
    Morrison, Ashby J.
    [J]. MOLECULAR METABOLISM, 2020, 38
  • [3] Chromatin modifications: implications in the regulation of gene expression in Toxoplasma gondii
    Bougdour, Alexandre
    Braun, Laurence
    Cannella, Dominique
    Hakimi, Mohamed-Ali
    [J]. CELLULAR MICROBIOLOGY, 2010, 12 (04) : 413 - 423
  • [4] Chromatin modifications by methylation and ubiquitination: Implications in the regulation of gene expression
    Shilatifard, Ali
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 : 243 - 269
  • [5] Regulation of chromatin and gene expression by metabolic enzymes and metabolites
    Xinjian Li
    Gabor Egervari
    Yugang Wang
    Shelley L. Berger
    Zhimin Lu
    [J]. Nature Reviews Molecular Cell Biology, 2018, 19 : 563 - 578
  • [6] Regulation of chromatin and gene expression by metabolic enzymes and metabolites
    Li, Xinjian
    Egervari, Gabor
    Wang, Yugang
    Berger, Shelley L.
    Lu, Zhimin
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018, 19 (09) : 563 - 578
  • [7] Metabolic Reprogramming and Signaling to Chromatin Modifications in Tumorigenesis
    Diaz-Hirashi, Zyanya
    Gao, Tian
    Verdeguer, Francisco
    [J]. TUMOR MICROENVIRONMENT: THE MAIN DRIVER OF METABOLIC ADAPTATION, 2020, 1219 : 225 - 241
  • [8] Chromatin modifications remodel cardiac gene expression
    Mathiyalagan, Prabhu
    Keating, Samuel T.
    Du, Xiao-Jun
    El-Osta, Assam
    [J]. CARDIOVASCULAR RESEARCH, 2014, 103 (01) : 7 - 16
  • [9] Guided by COMPASS on a journey through chromatin modifications, regulation of gene expression and the pathogenesis of leukemia
    Shilatifard, A
    [J]. FASEB JOURNAL, 2006, 20 (05): : A849 - A849
  • [10] Epigenetic regulation of hypoxia-responsive gene expression: Focusing on chromatin and DNA modifications
    Tsai, Ya-Ping
    Wu, Kou-Juey
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2014, 134 (02) : 249 - 256
12345