Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis

被引：159

作者：

Zinoviev, Kirill E. ^{[1
]}

Belen Gonzalez-Guerrero, Ana ^{[2
,3
]}

Dominguez, Carlos ^{[1
]}

Lechuga, Laura M. ^{[2
,3
]}

机构：

[1] CNM CSIC, Inst Microelect Barcelona, Micro & Nanosyst Dept, Barcelona 08193, Spain

[2] CIN2 CSIC ICN, Nanobiosensors & Bioanalyt Applicat Grp, Barcelona 08193, Spain

[3] CIBER BBN, Barcelona 08193, Spain

来源：

JOURNAL OF LIGHTWAVE TECHNOLOGY | 2011年 / 29卷 / 13期

关键词：

Bimodal waveguide; evanescent wave detection; integrated optics; optical biosensors; waveguides; SENSOR;

D O I：

10.1109/JLT.2011.2150734

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5.10(-7) RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis.

引用

页码：1926 / 1930

页数：5

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