One-pot synthesis of pyrazoline derivatised carbazoles as antitubercular, anticancer agents, their DNA cleavage and antioxidant activities

被引：101

作者：

Taj, Tasneem ^{[1
]}

Kamble, Ravindra R. ^{[1
]}

Gireesh, T. M. ^{[1
]}

Hunnur, Raveendra K. ^{[1
]}

Margankop, Sheetal B. ^{[1
]}

机构：

[1] Karnatak Univ, PG Dept Studies Chem, Dharwad 580003, Karnataka, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 09期

关键词：

Sydnones; Pyrazolines; Carbazoles; MIC; Antitubercular; Anticancer; DISEASE; DAMAGE;

D O I：

10.1016/j.ejmech.2011.07.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel tricyclic carbazoles 4a-k were synthesized in one-pot employing sydnone derivatives 3a-k as masked hydrazines by the ring transformation in presence of conc. HCl and cyclohexanone. The title compounds were screened for anti-tubercular, anti cancer, DNA cleavage, antioxidant activity. MIC, GI50, LC50, TGI were evaluated. The title compounds have exhibited significant antitubercular, DNA cleavage and antioxidant activities and partial anticancer activity. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：4366 / 4373

页数：8

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