Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides

被引：66

作者：

Hazelden, Ian R. ^{[1
]}

Ma, Xiaofeng ^{[1
]}

Langer, Thomas ^{[2
]}

Bower, John F. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] AstraZeneca, Pharmaceut Technol & Dev, Charter Way, Macclesfield SK10 2NA, Cheshire, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 37期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

aza-Heck reaction; cascade reactions; N-heterocycles; palladium; PALLADIUM-CATALYZED CYCLIZATIONS; OXIME ESTERS; ALKENES SYNTHESIS; BONDS; DIHYDROPYRROLES; AMINATION; INSIGHTS; OXYGEN; ALKYL;

D O I：

10.1002/anie.201605152

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aza-Heck cyclizations initiated by oxidative addition of Pd-0-catalysts into the N-O bond of N-(pentafluoro-benzoyloxy)sulfonamides are described. These studies, which encompass only the second class of aza-Heck reaction developed to date, provide direct access to diverse N-heterocyclic ring systems.

引用

页码：11198 / 11202

页数：5

共 40 条

[1] Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates
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[10] Nazarov Cyclization/Internal Redox Cyclization Sequence for the Synthesis of N-Heterocyclic Bridged Ring Systems
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