Efficient Synthesis of 2-(2-Aminophenyl)-2,3-dihydropyridin-4(1H)-ones Based on a Cyclization/Ring Cleavage Procedure

被引：4
|
作者：
Karapetyan, Vahuni [1 ,2 ]
Mkrtchyan, Satenik [1 ,2 ]
Karapetyan, Gnuni [1 ]
Villinger, Alexander [1 ]
Saghiyan, Ashot [2 ,3 ]
Ghochikyan, Tariel V. [2 ]
Langer, Peter [1 ,4 ]
机构：
[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany
[2] Yerevan State Univ, Fac Chem, Yerevan 0025, Armenia
[3] CJSC Sci Res Inst Biotechnol, Yerevan 0056, Armenia
[4] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
来源：
HELVETICA CHIMICA ACTA | 2011年 / 94卷 / 11期
关键词：
Quinazolines; Pyridin-4(1H)-ones; Silyl enol ethers; X-Ray crystallography; ENOL ETHERS);
D O I：
10.1002/hlca.201100130
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Benzyloxycarbonyl)-protected 3,4-benzo-7-hydroxy-2,9-diazabicyclo[3.3.1]non-7-enes were prepared by one-pot cyclizations of 1,3-bis(silyl enol ethers) with quinazolines. Subsequent hydrogenation resulted in one-pot deprotection and rearrangement to give 2-(2-aminophenyl)-2,3-dihydropyridin-4(1H)-ones.
引用
收藏
页码：2045 / 2053
页数：9
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