Synthesis of α-Ketoamides via Electrochemical Decarboxylative Acylation of Isocyanides Using α-Ketoacids as an Acyl Source

被引：0

作者：

Zhao, Yuhan ^{[1
]}

Meng, Xia ^{[1
]}

Cai, Changqun ^{[1
]}

Wang, Lingyun ^{[1
,2
]}

Gong, Hang ^{[1
]}

机构：

[1] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China

[2] Hunan Inst Technol, Sch Mat & Chem Engn, Hengyang 421002, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 04期

关键词：

alpha-ketoamide; acylation; catalyst-free; decarboxylation; electrochemistry; CATALYZED DOUBLE CARBONYLATION; POTENT THROMBIN INHIBITORS; CATHEPSIN S INHIBITORS; OXOCARBOXYLIC ACIDS; EFFICIENT SYNTHESIS; MINISCI ACYLATION; KETO AMIDES; CHLORIDES; DESIGN; CYCLOTHEONAMIDES;

D O I：

10.1002/ajoc.202100748

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalyst-, transition metal-, oxidant-free strategy for the synthesis of alpha-ketoamides via an electrochemical decarboxylative acylation of isocyanides at room temperature with carbon dioxide as a sole by-product was developed in this work. This is a simple, rapid and practical strategy under mild conditions for synthesizing highly functionalized alpha-ketoamides with high atom economy.

引用

页数：5

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