Regio- and Enantioselective Allylic Substitution with Less Active N- or O-Nucleophiles Catalyzed by Iridium-Complex of Bis(oxazolinyl)pyridine

被引：10
|
作者：
Miyabe, Hideto [1 ,2 ]
Moriyama, Katsuhiko [1 ]
Takemoto, Yoshiji [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
[2] Hyogo Univ Hlth Sci, Sch Pharm, Chuo Ku, Kobe, Hyogo 6508530, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 06期
关键词：
allylic substitution; catalytic; enantioselective; iridium; ASYMMETRIC TOTAL-SYNTHESIS; ALLYLATED OXIME ETHERS; STEREOSELECTIVE-SYNTHESIS; PHOSPHORAMIDITE LIGANDS; KINETIC RESOLUTION; AMINATION REACTION; CHIRAL LIGANDS; ETHERIFICATION; CARBONATES; PALLADIUM;
D O I：
10.1248/cpb.59.714
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The utility of hydroxylamines as nitrogen nucleophiles was investigated in the iridium-catalyzed regio- and enantioselective allylic substitution. Allylic substitution with hydroxylamines proceeded with good enantioselectivities by using the iridium-complex of bis(oxazolinyl)pyridine ligand. The good regio- and enantioselectivities were also achieved in the reaction with alkylamines, p-anisidine, and 4-methoxyphenol.
引用
收藏
页码：714 / 720
页数：7
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