A free boundary problem for an elliptic-hyperbolic system: An application to tumor growth

被引:90
|
作者
Chen, XF [1 ]
Friedman, A
机构
[1] Univ Pittsburgh, Dept Math, Pittsburgh, PA 15260 USA
[2] Ohio State Univ, Dept Math, Columbus, OH 43210 USA
关键词
free boundary problem; elliptic-hyperbolic system; tumor growth;
D O I
10.1137/S0036141002418388
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
We consider a system of two hyperbolic equations for p, q and two elliptic equations for c, sigma, where p, q are the densities of cells within the tumor Omega(t) in proliferating and quiescent states, respectively, c is the concentration of nutrients, and s is the pressure. The pressure is a result of the transport of cells which proliferate or die. The motion of the free boundary partial derivativeOmega(t) is given by the continuity condition, and sigma at the free boundary is proportional to the surface tension. We prove the existence, uniqueness, and regularity of the solution for a small time interval 0 less than or equal to t less than or equal to T.
引用
收藏
页码:974 / 986
页数:13
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