Neuroleptic-induced acute and chronic akathisia: A clinical comparison

We compared the severity of subjective and objective symptomatology of akathisia between the acute and chronic subtypes of neuroleptic-induced akathisia. Sixty-one schizophrenic subjects were evaluated. Multivariate analysis revealed that motor manifestations and distress of akathisia were less severe in chronic akathisia than in acute akathisia. The severity of subjective restlessness was not significantly different between the two groups. In conclusion, there were differences in the severity of symptoms and signs between the acute and chronic subtypes of akathisia, suggesting that the severity of the subjective and objective components of akathisia may be differentially affected by the duration of akathisia. (c) 2005 Movement Disorder Society.