Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse

被引：22

作者：

Seino, Satoshi ^{[1
]}

Tanaka, Yurie ^{[1
]}

Honma, Taro ^{[1
]}

Yanaka, Miyuki ^{[1
]}

Sato, Kenta ^{[1
]}

Shinohara, Nahoko ^{[1
]}

Ito, Junya ^{[1
]}

Tsuduki, Tsuyoshi ^{[1
]}

Nakagawa, Kiyotaka ^{[2
]}

Miyazawa, Teruo ^{[2
]}

Ikeda, Ikuo ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr, Lab Food & Biomol Sci, Sendai, Miyagi 9818555, Japan

[2] Tohoku Univ, Grad Sch Agr, Food & Biodynam Chem Lab, Sendai, Miyagi 9818555, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2012年 / 50卷 / 02期

关键词：

allergy; DNA microarray; lipid metabolism; liver; NC/Nga; CONJUGATED TRIENE SYSTEM; ALPHA-ELEOSTEARIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; FOOD-INTAKE; TNF-ALPHA; OBESITY; P53; DISEASE; APOPTOSIS;

D O I：

10.3164/jcbn.11-29

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Various factors have been reported to influence lipid metabolism and cause metabolic syndrome. However, the influence of allergy on the liver that plays important role of lipid metabolism has not been clarified. The aim of this study was to examine the influence of allergy on lipid metabolism of liver. A model of atopic dermatitis was developed in the NC/Nga mouse using picryl chloride to induce allergy. Lipid metabolism parameters were measured and the mechanism of changes in these parameters was examined using DNA microarray analysis and quantitative reverse transcriptase PCR. Triacylglycerol accumulation was promoted in the liver in the mouse atopic dermatitis model despite reductions in food intake, body weight gain, and serum glucose. As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid beta-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver.

引用

页码：152 / 157

页数：6

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