Recombinant factor VIIa use in patients presenting with intracranial hemorrhage

被引：3
|
作者：
Yampolsky, Natalie [1 ]
Stofko, Douglas [2 ]
Veznedaroglu, Erol [2 ]
Liebman, Kenneth [2 ]
Binning, Mandy J. [2 ]
机构：
[1] Capital Hlth Reg Med Ctr, Dept Pharm, Trenton, NJ 08534 USA
[2] Capital Inst Neurosci, Dept Neurosurg, Trenton, NJ USA
来源：
SPRINGERPLUS | 2014年 / 3卷
关键词：
Recombinant factor VIIa; Intracranial hemorrhage; International Normalized Ratio; Anticoagulation; Neurosurgery; Stroke; ACTIVATED FACTOR-VII; WARFARIN; ANTICOAGULATION; SAFETY;
D O I：
10.1186/2193-1801-3-471
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recombinant factor VIIa (rFVIIa) can be used for rapid INR normalization in life-threatening hemorrhage in anticoagulated patients. Dosing is unclear and may carry thromboembolic risks. We reviewed the use of rFVIIa at a comprehensive stroke and cerebrovascular center to evaluate dose effectiveness on INR reduction and thromboembolic complications experienced. The primary endpoint was to review the efficacy of rFVIIa in lowering INR. Secondary endpoints included doses used and adverse effects caused by rFVIIa administration. Forty-one percent of patients presented with a subdural hemorrhage. The mean INR prior to rFVIIa administration was 3.5 (0.9-15) and decreased to 1.13 (0.6-2). The mean dose of rFVIIa given was 73 mcg/kg (+/- 24 mcg/kg). Two patients (3%) experienced a thromboembolic event. Recombinant factor VIIa appears to lower INR without significant thromboembolic complications.
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页数：5
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