In vivo three-dimensional optical coherence elastography

被引：131
|
作者：
Kennedy, Brendan F. [1 ]
Liang, Xing [2 ,3 ]
Adie, Steven G. [2 ]
Gerstmann, Derek K. [4 ,5 ]
Quirk, Bryden C. [1 ]
Boppart, Stephen A. [2 ,3 ,6 ,7 ]
Sampson, David D. [1 ,4 ]
机构：
[1] Univ Western Australia, Sch Elect Elect & Comp Engn, Opt Biomed Engn Lab, Crawley, WA 6009, Australia
[2] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA
[3] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
[4] Univ Western Australia, Ctr Microscopy Characterisat & Anal, Crawley, WA 6009, Australia
[5] Univ Western Australia, iVEC, Crawley, WA 6009, Australia
[6] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA
[7] Univ Illinois, Dept Med, Urbana, IL 61801 USA
来源：
OPTICS EXPRESS | 2011年 / 19卷 / 07期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
MAGNETIC-RESONANCE ELASTOGRAPHY; IMAGING ELASTIC PROPERTIES; TOMOGRAPHY; STRAIN; BREAST; DEFORMATION; DISEASE; TISSUES;
D O I：
10.1364/OE.19.006623
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum in the hydrated case. (C) 2011 Optical Society of America
引用
收藏
页码：6623 / 6634
页数：12
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