Catalepsy induced by the 5-HT1A receptor antagonist WAY 100635 in rats pretreated with the selective serotonin reuptake inhibitor citalopram

被引：3

作者：

Eltayb, A ^{[1
]}

Svensson, TH ^{[1
]}

Ahlenius, S ^{[1
]}

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 411卷 / 03期

关键词：

5-HT1A receptors; 5-HT; (5-hydroxytrypytamine; serotonin) reuptake inhibitor; selective; catalepsy; (Rat);

D O I：

10.1016/S0014-2999(00)00924-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neither a high dose of the selective serotonin reuptake inhibitor citalopram (100 mu mol kg(-1) s.c.), nor the 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperaziny]-N-ethyl]-N-(2-pyridinyl) cyclohexane carboxamide 3HCl (WAY 100635) (0.1-0.4 mu mol kg(-1) s.c.) produced any evidence of catalepsy in adult male rats. When combined with citalopram, however. WAY 100635 produced a dose-dependent, and statistically significant, catalepsy in the inclined grid test. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：275 / 277

页数：3

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