Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system

被引：64

作者：

Boekhoven, Job ^{[1
,2
]}

Zha, R. Helen ^{[1
,3
]}

Tantakitti, Faifan ^{[1
,3
]}

Zhuang, Ellen ^{[2
]}

Zandi, Roya ^{[2
]}

Newcomb, Christina J. ^{[1
]}

Stupp, Samuel I. ^{[1
,2
,3
,4
]}

机构：

[1] Simpson Querrey Inst BioNanotechnol, Chicago, IL 60611 USA

[2] Northwestern Univ, Dept Biomed Engn, Dept Chem Engn, Dept Chem, Evanston, IL 60208 USA

[3] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[4] Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

来源：

RSC ADVANCES | 2015年 / 5卷 / 12期

关键词：

SMALL MOLECULES; NANOFIBERS;

D O I：

10.1039/c4ra16593d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.

引用

页码：8753 / 8756

页数：4

共 50 条

[1] Composite core-shell microparticles from microfluidics for synergistic drug delivery
Li, Yanna
Yan, Dan
Fu, Fanfan
Liu, Yuxiao
Zhang, Bin
Wang, Jie
Shang, Luoran
Gu, Zhongze
Zhao, Yuanjin
[J]. SCIENCE CHINA-MATERIALS, 2017, 60 (06) : 543 - 553
[2] Fabrication of novel core-shell PLGA and alginate fiber for dual-drug delivery system
Wanawananon, Kwanchanok
Moulton, Simon E.
Wallace, Gordon G.
Liawruangrath, Saisunee
[J]. POLYMERS FOR ADVANCED TECHNOLOGIES, 2016, 27 (08) : 1014 - 1019
[3] Synthesis of uniform core-shell gelatin-alginate microparticles as intestine-released oral delivery drug carrier
Huang, Keng-Shiang
Yang, Chih-Hui
Kung, Chao-Ping
Grumezescu, Alexandru Mihai
Ker, Ming-Dou
Lin, Yung-Sheng
Wang, Chih-Yu
[J]. ELECTROPHORESIS, 2014, 35 (2-3) : 330 - 336
[4] Core-shell alginate@silica microparticles encapsulating probiotics
Haffner, F. B.
Girardon, M.
Fontanay, S.
Canilho, N.
Duval, R. E.
Mierzwa, M.
Etienne, M.
Diab, R.
Pasc, A.
[J]. JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (48) : 7929 - 7935
[5] One-step fabrication of core-shell structured alginate-PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs
Lim, Ming Pin Alan
Lee, Wei Li
Widjaja, Effendi
Loo, Say Chye Joachim
[J]. BIOMATERIALS SCIENCE, 2013, 1 (05) : 486 - 493
[6] A perspective on magnetic core-shell carriers for responsive and targeted drug delivery systems
Albinali, Kholoud E.
Zagho, Moustafa M.
Deng, Yonghui
Elzatahry, Ahmed A.
[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14 : 1707 - 1723
[7] Core-shell magnetic nanoparticle carrier for targeted drug delivery: challenges and design
Misra, R. D. K.
[J]. MATERIALS TECHNOLOGY, 2010, 25 (3-4) : 118 - 126
[8] A facile fabrication of core-shell sodium alginate/gelatin beads for drug delivery systems
Guo, Ting
Zhang, Ning
Huang, Jinbao
Pei, Ying
Wang, Fang
Tang, Keyong
[J]. POLYMER BULLETIN, 2019, 76 (01) : 87 - 102
[9] Macropored microparticles with a core-shell architecture for oral delivery of biopharmaceuticals
Homayun, Bahman
Kumar, Ankit
Nascimento, Priscila T. H.
Choi, Hyo-Jick
[J]. ARCHIVES OF PHARMACAL RESEARCH, 2018, 41 (08) : 848 - 860
[10] Drug loaded microparticles with core-shell structure and their drug release property
[J]. Rong, J.-H., 1600, Journal of Functional Materials, P.O. Box 1512, Chongqing, 630700, China (44):

← 1 2 3 4 5 →