Dammarane-type saponins from Gynostemma pentaphyllum and their cytotoxicities

被引：14
|
作者：
Cui, Wei-Ye [1 ,2 ]
Jin, Yulian [3 ]
Liu, Hui [1 ,2 ]
Zu, Ma-Li [1 ,2 ]
Zhai, Xin-Fang [1 ,2 ]
Yang, Ce [1 ,2 ]
Gu, Yu-Long [1 ,2 ]
Cheng, Yong [1 ,2 ]
Piao, Xiang-Lan [1 ,2 ]
机构：
[1] Minzu Univ China, Ctr Translat Neurosci, Beijing, Peoples R China
[2] Minzu Univ China, Sch Pharm, Beijing, Peoples R China
[3] Tianjin Univ Commerce, Sch Biotechnol & Food Sci, Tianjin, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期
基金：
国家重点研发计划;
关键词：
Gynostemma pentaphyllum; saponin; damulin E; damulin F; cytotoxicity; SIGNALING PATHWAY; APOPTOSIS; A549; INHIBITION; ACTIVATION; PROTEIN-1; INDUCTION; CELLS; RAT;
D O I：
10.1080/14786419.2020.1723093
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Heat-processed Gynostemma pentaphyllum has shown strong activity against human lung carcinoma A549 cells. In this study, two dammarane-type saponins together with two known compounds were isolated from the ethanol extract of the heat-processed leaves of G. pentaphyllum. They were identified as 2 alpha,3 beta,12 beta-trihydroxydammar-20(22),24-diene-3-O-beta-D-glucopyranoside (1, namely damulin E), 2 alpha,3 beta,12 beta-trihydroxydammar-20,24-diene-3-O-beta-D-glucopyranoside (2, namely damulin F), damulin A (3) and damulin B (4), respectively, using NMR and mass spectra. Damulin E and damulin F showed moderate activity against A549, H1299, T24, SH-SY5Y and K562 cell lines in vitro using CCK-8 assay.
引用
收藏
页码：4433 / 4441
页数：9
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