Towards a modular approach for heparin synthesis

被引：50

作者：

Haller, M ^{[1
]}

Boons, GJ ^{[1
]}

机构：

[1] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 08期

关键词：

D O I：

10.1039/b009845k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trisaccharide 23 and sulfated disaccharide 28 have been prepared by a strategy whereby the glucuronic acid moieties were introduced at a late stage of a synthetic sequence by selective oxidation of primary hydroxy groups with TEMPO and NaOCl. During the oxidation step, the primary hydroxy groups of glucosamine moieties were efficiently protected as TBDPS ethers. The oxidation procedure and removal of the TBDPS groups proved to be compatible with the presence of sulfate esters.

引用

页码：814 / 822

页数：9

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