Exposure modelling in Europe: how to pave the road for the future as part of the European Exposure Science Strategy 2020-2030

被引:10
|
作者
Schlueter, Urs [1 ]
Meyer, Jessica [1 ]
Ahrens, Andreas [2 ]
Borghi, Francesca [3 ]
Clerc, Frederic [4 ]
Delmaar, Christiaan [5 ]
Di Guardo, Antonio [3 ]
Dudzina, Tatsiana [6 ]
Fantke, Peter [7 ]
Fransman, Wouter [8 ]
Hahn, Stefan [9 ]
Heussen, Henri [10 ]
Jung, Christian [11 ]
Koivisto, Joonas [12 ]
Koppisch, Dorothea [13 ]
Paini, Alicia [14 ]
Savic, Nenad [15 ]
Spinazze, Andrea [3 ]
Zare Jeddi, Maryam [5 ]
von Goetz, Natalie [16 ,17 ]
机构
[1] Fed Inst Occupat Safety & Hlth BAuA, Friedrich Henkel Weg 1-25, D-44149 Dortmund, Germany
[2] European Chem Agcy ECHA, Exposure & Supply Chain Unit, POB 400, FI-00121 Helsinki, Finland
[3] Univ Insubria, Dept Sci & High Technol, I-22100 Como, Italy
[4] Natl Inst Res & Safety INRS, Pollutants Metrol Div, Nancy, France
[5] Natl Inst Publ Hlth & Environm RIVM, Antonie Leeuwenhoeklaan 9, NL-3721 MA Bilthoven, Netherlands
[6] Exxon Mobil Petr & Chem BV, Hermeslaan 2, Machelen 1831, Belgium
[7] Tech Univ Denmark, Dept Environm & Resource Engn, Quantitat Sustainabil Assessment, Produktionstorvet 424, DK-2800 Lyngby, Denmark
[8] TNO, Dept Risk Anal Prod Dev, POB 80015, NL-3508 TA Utrecht, Netherlands
[9] Fraunhofer Inst Toxicol & Expt Med ITEM, Nikolai Fuchs Str 1, D-30625 Hannover, Germany
[10] Cosanta BV, Stn Pl Noord Oost 202, NL-1117 CJ Schiphol, Netherlands
[11] German Fed Inst Risk Assessment BfR, Max Dohrn Str 8 10, D-10589 Berlin, Germany
[12] Univ Helsinki, Inst Atmospher & Earth Syst Res INAR, PL 64, Helsinki, Finland
[13] Inst Occupat Safety & Hlth German Social Accid In, Sect 13 Exposure Monitoring MGU, Alte Heerstr 111, D-53757 St Augustin, Germany
[14] European Commiss Joint Res Ctr JRC, Ispra, Italy
[15] Ctr Primary Care & Publ Hlth, Unisante,Route Corniche 2, CH-1066 Epalinges, Switzerland
[16] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Ramistr 101, CH-8092 Zurich, Switzerland
[17] Swiss Fed Off Publ Hlth FOPH, Schwarzenburgstr 157, CH-3003 Bern, Switzerland
关键词
Exposure models; European Exposure Science Strategy; ISES Europe; MOLECULAR-DYNAMICS SIMULATION; ADVANCED REACH TOOL; RISK-ASSESSMENT; UNION SYSTEM; MERLIN-EXPO; CHEMICALS; RELIABILITY; VALIDATION; SUBSTANCES; MULTIMEDIA;
D O I
10.1038/s41370-022-00455-4
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Exposure models are essential in almost all relevant contexts for exposure science. To address the numerous challenges and gaps that exist, exposure modelling is one of the priority areas of the European Exposure Science Strategy developed by the European Chapter of the International Society of Exposure Science (ISES Europe). A strategy was developed for the priority area of exposure modelling in Europe with four strategic objectives. These objectives are (1) improvement of models and tools, (2) development of new methodologies and support for understudied fields, (3) improvement of model use and (4) regulatory needs for modelling. In a bottom-up approach, exposure modellers from different European countries and institutions who are active in the fields of occupational, population and environmental exposure science pooled their expertise under the umbrella of the ISES Europe Working Group on exposure models. This working group assessed the state-of-the-art of exposure modelling in Europe by developing an inventory of exposure models used in Europe and reviewing the existing literature on pitfalls for exposure modelling, in order to identify crucial modelling-related strategy elements. Decisive actions were defined for ISES Europe stakeholders, including collecting available models and accompanying information in a living document curated and published by ISES Europe, as well as a long-term goal of developing a best-practices handbook. Alongside these actions, recommendations were developed and addressed to stakeholders outside of ISES Europe. Four strategic objectives were identified with an associated action plan and roadmap for the implementation of the European Exposure Science Strategy for exposure modelling. This strategic plan will foster a common understanding of modelling-related methodology, terminology and future research in Europe, and have a broader impact on strategic considerations globally.
引用
收藏
页码:499 / 512
页数:14
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