Expressing patterns of p16 and CDK4 correlated to prognosis in colorectal carcinoma

被引：0
|
作者：
Zhao, P
Hu, YC
Talbot, IC
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Pathol, Beijing 100853, Peoples R China
[2] Canc Res UK, Colorectal Canc Unit, St Marks Hosp, Acad Dept Pathol, Harrow HA1 3UJ, Middx, England
[3] Sichuan Univ, Huaxi Med Coll, Dept Pathol, Chengdu 610041, Peoples R China
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2003年 / 9卷 / 10期
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D O I：
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中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: To describe the correlation between innunostaining patterns of p16 and CDK4 and prognosis in colorectal carcinoma. METHODS: Paraffin sections of 74 cases of colorectal carcinoma were analysed immunohistochemically for expression of p16 and CDK4 proteins. RESULTS: Most carcinomas showed stronger p16 and CDK4 immunostaining in the cytoplasm than the adenomas or the adjacent normal mucosa. Strong immunostaining of p16 was a predictor for better prognosis whereas strong cytoplasmic immunostaining of CDK4 was a predictor for poor prognosis. Both p16 and CDK4 immunostainings were correlated with histological grade or Dukes' stage. CONCLUSION: These results support the experimental evidence that interaction of expression of p16 and CDK4 may play an important role in the Rb/p16 pathway, and the expression paterns of CDK4 and p16 may be imperative in the development of colorectal carcinoma, thus becoming a new prognostic marker in colorectal cancer.
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页码：2202 / 2206
页数：5
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