Bioadaptation of implants to In vitro and In vivo oxidative stress pathological conditions via nanotopography-induced FoxO1 signaling pathways to enhance Osteoimmunal regeneration

被引:30
|
作者
Huang, Jingyan [1 ,2 ]
Li, Ruoqi [1 ,2 ]
Yang, Jinghong [1 ,2 ]
Cai, Min [1 ,2 ]
Lee, Yichen [1 ,2 ]
Wang, Anxun [3 ]
Cheng, Bin [1 ,2 ]
Wang, Yan [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Guanghua Sch Stomatol, Hosp Stomatol, Guangzhou 510055, Guangdong, Peoples R China
[2] Guangdong Key Lab Stomatol, Guangzhou 510055, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Oral & Maxillofacial Surg, Guangzhou 510080, Guangdong, Peoples R China
关键词
Oxidative stress; Osteogenesis; TiO2; nanotubes; FoxO(1); Inflammation; MESENCHYMAL STEM-CELLS; OSTEOGENESIS; HOMEOSTASIS; TOPOGRAPHY; NANOTUBES; PHENOTYPE; SURVIVAL; RATES; NRF2;
D O I
10.1016/j.bioactmat.2021.02.023
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Varieties of pathological conditions, including diabetes, are closely related to oxidative stress (OS), but the osseointegration or bioadaptation of implants to OS and the related mechanism remain poorly explored. In this study, the antioxidation and osteoimmune regeneration of titanium implants with micro/nanotopographies were evaluated under H2O2-, lipopolysaccharide (LPS)- and hyperglycemia-mediated cellular OS models and in diabetic rats as a representative animal model of OS. TiO2 nanotube (TNT) coating on titanium implants directly induced superior osteogenic differentiation of bone mesenchymal stem cells (MSCs) and osseointegration compared with microscale sand blasted-acid etched topography (SLA) under OS, attributed to higher superoxide dismutase 2 activity, the neutralization of intracellular reactive oxygen species (ROS), and less apoptosis. Mechanistically, the oxidation resistance on TNT is driven by upregulated forkhead box transcription factor O1 (FoxO1), which is abolished after knockdown of FoxO1 via shRNA in MSCs. Indirectly, TNT also alleviates OS in macrophages, therefore inducing a higher portion of the M2 phenotype under OS with increased secretion of the anti-inflammatory cytokine IL-10, further promoting the osseoimmunity capacity compared with SLA. The current study not only suggests the potential application of TiO2 nanotube-coated titanium implants in compromised conditions but also provides a systematic evaluation strategy for the future development of bone biomaterials.
引用
收藏
页码:3164 / 3176
页数:13
相关论文
共 11 条
  • [1] Columbianadin attenuates doxorubicin-induced cardiac injury, oxidative stress, and apoptosis via Sirt1/FOXO1 signaling pathway
    Peng, Bo
    Rao, Li
    Yang, Jiaolong
    Ku, Xiaowei
    Kong, Bin
    Shuai, Wei
    Huang, He
    [J]. ACTA CIRURGICA BRASILEIRA, 2023, 38
  • [2] Piceatannol protects against cerebral ischemia/reperfusion-induced apoptosis and oxidative stress via the Sirt1/FoxO1 signaling pathway
    Wang, Kai-Jie
    Zhang, Wen-Qian
    Liu, Jing-Jing
    Cui, Ying
    Cui, Jian-Zhong
    [J]. MOLECULAR MEDICINE REPORTS, 2020, 22 (06) : 5399 - 5411
  • [3] Naringenin attenuates cerebral ischemia/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/FOXO1 signaling pathway in vitro
    Zhao, Peng
    Lu, Yi
    Wang, Zhiyun
    [J]. ACTA CIRURGICA BRASILEIRA, 2023, 38 (01)
  • [4] Asiatic acid improves high-fat-diet-induced osteoporosis in mice via regulating SIRT1/FOXO1 signaling and inhibiting oxidative stress
    Chen, Xiaosi
    Hang, Dengpeng
    Liu, Tianfeng
    Huang, Chengshuo
    Hu, Zibing
    Tang, Xiaoyan
    Wu, Shaoke
    [J]. HISTOLOGY AND HISTOPATHOLOGY, 2022, 37 (08) : 769 - 777
  • [5] Melatonin Attenuates Oxidative Stress-Induced Apoptosis of Bovine Ovarian Granulosa Cells by Promoting Mitophagy via SIRT1/FoxO1 Signaling Pathway
    Xu, Gaoqing
    Dong, Yangyunyi
    Wang, Zhe
    Ding, He
    Wang, Jun
    Zhao, Jing
    Liu, Hongyu
    Lv, Wenfa
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (16)
  • [6] MiR-184 targeting FOXO1 regulates host-cell oxidative stress induced by Chlamydia psittaci via the Wnt/β-catenin signaling pathway
    Chen, Lili
    Huang, Qiaoling
    Luo, Yuchen
    Zhou, You
    Tong, Ting
    Chen, Yuyu
    Bai, Qinqin
    Lu, Chunxue
    Li, Zhongyu
    [J]. INFECTION AND IMMUNITY, 2023, 91 (11)
  • [7] 5,7-Dihydroxy-4-methylcoumarin modulates the JNK/FoxO1 signaling pathway to attenuate cisplatin-induced ototoxicity by suppressing oxidative stress and apoptosis in vitro
    Li, Cai
    Wang, Xue
    Qiao, Xiangyun
    Fan, Li
    Zhu, Huanhuan
    Chen, Yutao
    He, Yingzi
    Zhang, Zhiyuan
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2023, 1870 (04):
  • [8] CD28 Deficiency Ameliorates Blast Exposure-Induced Lung Inflammation, Oxidative Stress, Apoptosis, and T Cell Accumulation in the Lungs via the PI3K/Akt/FoxO1 Signaling Pathway
    Liu, Yunen
    Tong, Changci
    Xu, Ying
    Gong, Peifang
    Liu, Ying
    Shi, Lin
    Shi, Xiuyun
    Zhao, Yan
    Bi, Guangyuan
    Jin, Hongxu
    Hou, Mingxiao
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 2019
  • [9] l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells
    Zhao, Ye
    Jiang, Qin
    Zhang, Xuefei
    Zhu, Xiaoxiao
    Dong, Xia
    Shen, Linyuan
    Zhang, Shunhua
    Niu, Lili
    Chen, Lei
    Zhang, Ming
    Jiang, Jun
    Chen, Daiwen
    Zhu, Li
    [J]. ANTIOXIDANTS, 2021, 10 (12)
  • [10] Coenzyme Q10 protects hepatocytes from ischemia reperfusion-induced apoptosis and oxidative stress via regulation of Bax/Bcl-2/PUMA and Nrf-2/FOXO-3/Sirt-1 signaling pathways
    Mahmoud, Amany R.
    Ali, Fares E. M.
    Abd-Elhamid, Tarek Hamdy
    Hassanein, Emad H. M.
    [J]. TISSUE & CELL, 2019, 60 : 1 - 13