Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax

被引：48
|
作者：
Xu, Qingsong [1 ,3 ]
Dou, Hangli [1 ,3 ]
Wei, Peng [1 ,3 ]
Tan, Chengyu [1 ]
Yun, Xiaojing [2 ]
Wu, Yihong [2 ]
Bal, Xuefang [1 ]
Ma, Xiaojun [1 ]
Du, Yuguang [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Ctr Gene Res, Shanghai 200032, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2008年 / 71卷 / 04期
关键词：
chitooligosaccharides; hepatoma; apoptosis; Bax;
D O I：
10.1016/j.carbpol.2007.06.022
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Chitooligosaccharides (COS) have been shown to regulate various cellular and biological functions. However, the effect of COS on apoptosis of hepatocellular carcinoma cells remains unclear. In this study, the activity and mechanism of COS against human hepatocellular carcinoma cells (SMMC-7721 cells) were investigated in vitro. The experiments showed that COS notably induced the apoptosis of SMMC-7721 cells and increased the cleavage of poly(ADP-ribose) polymerase. It presented a dose-dependent manner, and the apoptotic rate amounted to about 38% after treatment with 0.8 mg/ml COS for 72 h. The mRNA and protein levels of Bax were up-regulated by COS. These results demonstrated that COS induced apoptosis of SMMC-7721 cells. The possible mechanism is that COS up-regulate pro-apoptotic protein Bax, and trigger the cells a start-up of the apoptosis program. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：509 / 514
页数：6
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