Pharmacokinetics of Levetiracetam in Neonates with Seizures

被引：55
|
作者：
Merhar, Stephanie L. [1 ]
Schibler, Kurt R. [1 ,3 ]
Sherwin, Catherine M. [2 ]
Meinzen-Derr, Jareen [1 ,3 ]
Shi, Jing [4 ]
Balmakund, Tonya [5 ]
Vinks, Alexander A. [2 ,3 ]
机构：
[1] Cincinnati Childrens Hosp, Div Neonatol, Med Ctr, Perinatal Inst, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp, Med Ctr, Div Clin Pharmacol, Cincinnati, OH USA
[3] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA
[4] Sichuan Univ, W China Univ Hosp 2, Div Neonatol, Chengdu 610064, Peoples R China
[5] Univ Arkansas Med Sci, Div Neurol, Little Rock, AR 72205 USA
来源：
JOURNAL OF PEDIATRICS | 2011年 / 159卷 / 01期
基金：
美国国家卫生研究院;
关键词：
YOUNG-CHILDREN; REFRACTORY EPILEPSY; SAFETY; EFFICACY; INFANTS; VARIABILITY; TRIAL; SIZE;
D O I：
10.1016/j.jpeds.2011.03.057
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect. (J Pediatr 2011; 159: 152-4)
引用
收藏
页码：152 / U184
页数：6
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