The effects of Caulerpa microphysa enzyme-digested extracts on ACE-inhibitory activity and in vitro anti-tumour properties

被引：22
|
作者：
Lin, Hui-Chiu [2 ]
Chou, Su-Tze [3 ]
Chuang, Mei-Yu [3 ]
Liao, Tzu-Yen [2 ]
Tsai, Wann-Sheng [2 ]
Chiu, Tsai-Hsin [1 ]
机构：
[1] Natl PengHu Univ Sci & Technol, Dept Food Sci, Makung City 880, Penghu County, Taiwan
[2] EY, COA, Penghu Marine Biol Res Ctr, Fisheries Res Inst, Makung City 880, Penghu County, Taiwan
[3] Providence Univ, Dept Food & Nutr, Taichung 43301, Taiwan
来源：
FOOD CHEMISTRY | 2012年 / 134卷 / 04期
关键词：
Caulerpa microphysa; Inhibited angiotensin converting enzyme; Anti-cancer ability; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITIES; DNA-DAMAGE; ANGIOTENSIN; PEPTIDE; ALGAE; SEAWEEDS; PROTEIN; WAKAME; JEJU;
D O I：
10.1016/j.foodchem.2012.04.105
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The aim of this study was to determine the ACE inhibitory activity and its anti-cancer properties of Caulerpa microphysa extracts. C. microphysa samples were digested with Flavourzyme, Alcalase, and pepsin. The ACE inhibitory activity of enzyme-digested C microphysa decreased in the order of digestion with pepsin > Flavourzyme > Alcalase; that is, pepsin-extracted samples had significantly higher activity than the other enzyme extractions. To test its anti-tumour effects in vitro C microphysa pepsin-digested extracts were applied to BALB/c mice with transplanted myelomonocytic leukaemia (WEHI-3) and Human promyelocytic leukaemia (HL-60) cell lines. The growth of both cell lines was inhibited, and extracts induced DNA damage, evaluated with a comet assay. The data demonstrate that C microphysa pepsin-digested extract had the ability to anti-tumour effects. Further application as a health food is worthy of investigation. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2235 / 2241
页数：7
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