HLA-B*5808, a new HLA-B allele characterized by sequence based typing

被引：6
|
作者：
Poli, F
Crespiatico, L
Frison, S
Longhi, E
Marlianici, E
Scalamogna, M
机构：
[1] IRCCS, Osped Maggiore Policlin, Ctr Trasfus & Immunol Trapianti, I-20122 Milan, Italy
[2] Azienda Osped Valtellina & Val Chiavenna Struttur, Serv Immunoematol & Med Transfus, Sondrio, Italy
[3] IRCCS, Osped Maggiore Policlin, Serv Prelievo & Conservaz Organi & Tessuti, I-20122 Milan, Italy
来源：
TISSUE ANTIGENS | 2003年 / 62卷 / 06期
关键词：
HLA; SBT;
D O I：
10.1046/j.1399-0039.2003.00111.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This brief communication describes a new HLA-B allele (HLA-B*5808) detected in an Italian white volunteer bone marrow donor. With serology, this subject was typed as HLA-B15,17, whereas with molecular biology B*15, B*51, B*52 and/or B*58 could be assigned. In order to clarify the results, direct and cloning sequencing of exons 2, 3 and 4 were carried out. This new allele is identical to HLA-B*5801 in exon 2 except for a silent point mutation at nucleotide 141 where a C is substituted by a T; exons 3 and 4 are typical of HLA-B*51, B*52 and B*78. The peculiar sequence of B*5808 could explain the discrepancy between the serological and molecular typing results.
引用
收藏
页码：551 / 553
页数：3
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