Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism

被引:31
|
作者
Choi, IG
Son, HG
Yang, BH
Kim, SH
Lee, JS
Chai, YG
Son, BK
Kee, BS
Park, BL
Kim, LH
Choi, YH
Shin, HD
机构
[1] SNP Genet Inc, Dept Genet Epidemiol, Seoul 153801, South Korea
[2] Hallym Univ Hangand Sacred Heart Hosp, Dept Neuropsychiat, Seoul, South Korea
[3] Hanyang Univ Hosp, Dept Neuropsychiat, Seoul, South Korea
[4] Kwandong Univ, Coll Med, Myongji Hosp, Dept Neuropsychiat, Goyang, South Korea
[5] Hanyang Univ, Coll Sci, Dept Biochem & Mol Biol, Ansan, South Korea
[6] Chuncheon Sacred Heart Hosp, Dept Neuropsychiat, Chunchon, South Korea
[7] Chung Ang Univ, Coll Med, Pildong Hosp, Dept Psychiat, Seoul 156756, South Korea
关键词
ADH1C; ADH1B; SNP; alcoholism; Korean;
D O I
10.1002/humu.20209
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Alcoholism is a multifactorial and polygenic disorder involving complex gene-to-gene and gene to -environment interactions. Alcohol metabolism is one of the biological determinants that could significantly be influenced by genetic polymorphisms in alcohol-metabolism genes. These genetic polymorphisms are believed to influence drinking behavior and development of alcoholism. Direct DNA sequencing of whole ADH1B and ADH1C genes revealed 36 sequence variants, including six nonsynonymous and 14 novel polymorphisms. Seventeen polymorphisms among them were selected for gencityping in a larger study (n = 352) based on linkage disequilibria (LDs) among SNPs, locations, and frequencies. Hardy-Weinberg equilibrium (HWE) analyses of polymorphisms revealed severe deviations only in alcoholics, which strongly suggest that a selection bias (or pressure) may be involved. The analyses of genotype distribution in alcoholics (n = 106) and normal controls (n = 246) showed dramatic associations with the risk of alcoholism. Fourteen polymorphisms in ADH1C and ADH1B showed a series of different strengths of association and magnitudes of risk. Based on referent and subgroup analysis, it was strongly suggested that the genetic effects come from the ADH1B*47Arg/*47Arg genotype, and that the positive signals from other sites are just tracking the genetic effect of ADH1B His47Arg. In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism. The information derived from this study could be valuable for understanding the genetic factors involved in the risk of alcoholism and facilitate further investigation in other ethnic groups.
引用
收藏
页码:224 / 234
页数:11
相关论文
共 50 条
  • [1] CYP2A13, ADH1B, and ADH1C Gene Polymorphisms and Pancreatic Cancer Risk
    Mohelnikova-Duchonova, Beatrice
    Vrana, David
    Holcatova, Ivana
    Ryska, Miroslav
    Smerhovsky, Zdenek
    Soucek, Pavel
    [J]. PANCREAS, 2010, 39 (02) : 144 - 148
  • [2] Association analysis of alcohol dehydrogenase ADH1B and ADH1C gene polymorphisms with alcohol dependence in Russian population of West Siberia
    Marusin, Andrey Victorovich
    Abushaeva, Marina Olegovna
    Kartashov, Georgy Alexandrovich
    Spiridonova, Maria Gennadievna
    Pels, Yanis Rudolfovich
    Bohan, Nikolay Alexandrovich
    Stepanov, Vadim Anatolievich
    [J]. CELLULAR ONCOLOGY, 2007, 29 (02) : 150 - 150
  • [3] Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis
    Vatansever, Sezgin
    Tekin, Fatih
    Salman, Esin
    Altintoprak, Ender
    Coskunol, Hakan
    Akarca, Ulus Salih
    [J]. BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2015, 15 (02) : 37 - 41
  • [4] Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma
    Ji, Yong Bae
    Lee, Seung Hwan
    Kim, Kyung Rae
    Park, Chul Won
    Song, Chang Myeon
    Park, Byung Lae
    Shin, Hyoung Doo
    Tae, Kyung
    [J]. TUMOR BIOLOGY, 2015, 36 (06) : 4387 - 4396
  • [5] Variability in Ethanol Biodisposition in Whites Is Modulated by Polymorphisms in the ADH1B and ADH1C Genes
    Martinez, Carmen
    Galvan, Segismundo
    Garcia-Martin, Elena
    Ramos, Maria I.
    Gutierrez-Martin, Yolanda
    Agundez, Jose A. G.
    [J]. HEPATOLOGY, 2010, 51 (02) : 491 - 500
  • [6] Determination of the effects of Alcohol Dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey
    Aktas, Ekin Ozgur
    Kocak, Aytac
    Senol, Ender
    Celik, Handan Ak
    Coskunol, Hakan
    Berdeli, Afig
    Aydin, Hikmet Hakan
    [J]. SCIENCE & JUSTICE, 2012, 52 (01) : 58 - 61
  • [7] ASSOCIATION OF ADH1B, ADH1C, PDYN AND DRD4 GENE POLYMORPHISMS WITH ALCOHOLISM IN RUSSIAN POPULATION OF WEST-SIBERIAN REGION
    Marusin, A.
    Simonova, K.
    Bokhan, N.
    Stepanov, V.
    [J]. INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH, 2013, 72 : 260 - 260
  • [8] Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population
    Way, Michael
    McQuillin, Andrew
    Saini, Jit
    Ruparelia, Kush
    Lydall, Gregory J.
    Guerrini, Irene
    Ball, David
    Smith, Iain
    Quadri, Giorgia
    Thomson, Allan D.
    Kasiakogia-Worlley, Katherine
    Cherian, Raquin
    Gunwardena, Priyanthi
    Rao, Harish
    Kottalgi, Girija
    Patel, Shamir
    Hillman, Audrey
    Douglas, Ewen
    Qureshi, Sherhzad Y.
    Reynolds, Gerry
    Jauhar, Sameer
    O'Kane, Aideen
    Dedman, Alex
    Sharp, Sally
    Kandaswamy, Radhika
    Dar, Karim
    Curtis, David
    Morgan, Marsha Y.
    Gurling, Hugh M. D.
    [J]. ADDICTION BIOLOGY, 2015, 20 (03) : 594 - 604
  • [9] ASSOCIATIONS OF ADH1B, ADH1C, AND ADH4 GENE VARIANTS, EDUCATION, AND ALCOHOL-RELATED PHENOTYPES IN BLACKS AND HISPANICS
    Chartier, K.
    Hesselbrock, V.
    Almasy, L.
    Hesselbrock, M.
    Edenberg, H.
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2013, 37 : 283A - 283A
  • [10] Alcohol intake, ADH1B and ADH1C genotypes, and the risk of colorectal cancer by sex and subsite in the Netherlands Cohort Study
    Offermans, Nadine S. M.
    Ketcham, Shannon M.
    van den Brandt, Piet A.
    Weijenberg, Matty P.
    Simons, Colinda C. J. M.
    [J]. CARCINOGENESIS, 2018, 39 (03) : 375 - 388