Animal model of Alzheimer's disease: characteristics of EEG and memory

被引：7
|
作者：
Mugantseva, Ekaterina A. [1 ]
Podolski, Igor Ya. [1 ]
机构：
[1] Pushchino State Univ, Russian Acad Sci, Lab Syst Org Neurons, Inst Theoret & Expt Biophys, Pushchino 142290, Russia
来源：
CENTRAL EUROPEAN JOURNAL OF BIOLOGY | 2009年 / 4卷 / 04期
关键词：
EEG; Spectral and correlation analysis; Hippocampus; Frontal cortex; Spatial memory; Amyloid beta-peptide; Alzheimer's disease; AMYLOID PRECURSOR PROTEIN; FUNCTIONAL CONNECTIVITY; PLASTICITY; BRAIN; ACETYLCHOLINE; IMPAIRMENT; DYNAMICS; DEFICITS; MICE; FORM;
D O I：
10.2478/s11535-009-0054-9
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We studied the effects of aggregated amyloid beta-peptide A beta(25-35) on spatial memory and the spectral-correlational characteristics of EEG of both the dorsal hippocampus and the frontal cortex both in adult and aged rats at the early stage of A beta(25-35) action. Spatial memory was characterized using a novel cognitive test. A decrease in low-frequency theta band oscillations in the dorsal hippocampus and the frontal cortex was observed. The mean coefficient of EEG cross-correlation between these structures was significantly reduced at the early stage of A beta(25-35) action both in adult and aged rats. In addition, we found that one month after A beta(25-35) injection spatial memory was impaired. These results suggest that the decrease in low-frequency theta band oscillations and the weakening of binding between the dorsal hippocampus and the frontal cortex under the action of A beta(25-35) may be an underlying cause of the typical memory breakdown associated with the Alzheimer's disease.
引用
收藏
页码：507 / 514
页数：8
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