Hyaluronan-CD44 axis orchestrates cancer stem cell functions

被引：86
|
作者：
Skandalis, Spyros S. [1 ]
Karalis, Theodoros T. [1 ]
Chatzopoulos, Athanasios [1 ]
Karamanos, Nikos K. [1 ]
机构：
[1] Univ Patras, Dept Chem, Lab Biochem, Biochem Biochem Anal & Matrix Pathobiol Res Grp, Patras 26500, Greece
来源：
CELLULAR SIGNALLING | 2019年 / 63卷
关键词：
Hyaluronan; CD44; Cancer stem cells (CSCs); Cancer niche; Drug resistance; EMT; Exosomes; EXTRACELLULAR-MATRIX; CD44; EXPRESSION; GROWTH-FACTOR; REACTIVE OXYGEN; DRUG-RESISTANCE; HYALURONIC-ACID; BREAST; DNA; NICHE; IDENTIFICATION;
D O I：
10.1016/j.cellsig.2019.109377
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The prominent role of CD44 in tumor cell signaling together with its establishment as a cancer stem cell (CSC) marker for various tumor entities imply a key role for CD44 in CSC functional properties. Hyaluronan, the main ligand of CD44, is a major constituent of CSC niche and, therefore, the hyaluronan-CD44 signaling axis is of functional importance in this special microenvironment. This review aims to provide recent advances in the importance of hyaluronan-CD44 interactions in the acquisition and maintenance of a CSC phenotype. Hyaluronan-CD44 axis has a substantial impact on sternness properties of CSCs and drug resistance through induction of EMT program, oxidative stress resistance, secretion of extracellular vesicles/exosomes and epigenetic control. Potential therapeutic approaches targeting CSCs based on the hyaluronan-CD44 axis are also presented.
引用
收藏
页数：9
相关论文
共 50 条
  • [1] Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities
    Toole, Bryan P.
    CLINICAL CANCER RESEARCH, 2009, 15 (24) : 7462 - 7468
  • [2] Hyaluronan-CD44 interactions as potential targets for cancer therapy
    Misra, Suniti
    Heldin, Paraskevi
    Hascall, Vincent C.
    Karamanos, Nikos K.
    Skandalis, Spyros S.
    Markwald, Roger R.
    Ghatak, Shibnath
    FEBS JOURNAL, 2011, 278 (09) : 1429 - 1443
  • [3] Mesenchymal Stem Cells Promote Proliferation of Breast Cancer Cells Via Hyaluronan-CD44 Interaction
    Kultti, A.
    Zimmerman, S.
    Huang, L.
    Jadin, L.
    Jiang, P.
    Frost, G. I.
    Shepard, H. M.
    Huang, J.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S79 - S79
  • [4] Atomistic fingerprint of hyaluronan-CD44 binding
    Vuorio, Joni
    Vattulainen, Ilpo
    Martinez-Seara, Hector
    PLOS COMPUTATIONAL BIOLOGY, 2017, 13 (07)
  • [5] Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis
    Heldin, Paraskevi
    Karousou, Eugenia
    Bernert, Berit
    Porsch, Helena
    Nishitsuka, Koichi
    Skandalis, Spyros S.
    CONNECTIVE TISSUE RESEARCH, 2008, 49 (3-4) : 215 - 218
  • [6] Hyaluronan-CD44/RHAMM interaction-dependent cell proliferation and survival in lung cancer cells
    Song, Jung Min
    Im, Jintaek
    Nho, Richard Seonghun
    Han, Yong Hwan
    Upadhyaya, Pramod
    Kassie, Fekadu
    MOLECULAR CARCINOGENESIS, 2019, 58 (03) : 321 - 333
  • [7] Hyaluronan-CD44 Interaction Promotes Oncogenic Signaling, microRNA Functions, Chemoresistance, and Radiation Resistance in Cancer Stem Cells Leading to Tumor Progression
    Bourguignon, Lilly Y. W.
    Shiina, Marisa
    Li, Jian-Jian
    HYALURONAN SIGNALING AND TURNOVER, 2014, 123 : 255 - 275
  • [8] Induction of Oocyte Maturation by Hyaluronan-CD44 Interaction in Pigs
    Yokoo, Masaki
    Kimura, Naoko
    Sato, Eimei
    JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2010, 56 (01): : 15 - 19
  • [9] The proinflammatory role of hyaluronan-CD44 interactions in renal injury
    Wüthrich, RP
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (11) : 2554 - 2556
  • [10] Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer
    Murai, Toshiyuki
    FRONTIERS IN IMMUNOLOGY, 2015, 6
12345