Synthesis of novel 2-phenylsulfonylhydrazono-3-(2′,3′,4′,6′-tetra-O-acetyl-β-D-glucopyranosyl)thiazolidine-4-ones from thiosemicarbazide precursors

被引：21

作者：

Li, Yu Xin ^{[1
]}

Wang, Su Hua ^{[1
]}

Li, Zheng Ming ^{[1
]}

Su, Na ^{[1
]}

Zhao, Wei Guang ^{[1
]}

机构：

[1] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 2006年 / 341卷 / 17期

基金：

中国国家自然科学基金;

关键词：

thiosemicarbazide; thiazolidine-4-one; fungicide;

D O I：

10.1016/j.carres.2006.09.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To develop novel biologically active organic compounds possessing a sugar moiety, a series of 2-phenylsulfonylhydrazono-3-(2',3',4',6'-tetra-O-acetyl-beta-D-glueopyranosyl)thiazolidine-4-one were synthesized via reaction of the thiosemicarbazide with ethyl bromoacetate. Their chemical structures were characterized by H-1 and C-13 NMR spectroscopy, elemental analysis and MS. The bioassay results indicated that some of these compound exhibit moderate fungicidal and herbicidal activities. Furthermore, the effect of various solvents at reflux temperature on the reactions of ethyl bromoacetate with the related thiosemicarbazides was investigated. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2867 / 2870

页数：4

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