p16 and p53 expression status in head and neck squamous cell carcinoma: a correlation with histological, histoprognostic and clinical parameters

被引:37
|
作者
Karpathiou, Georgia [1 ]
Monaya, Alessandra [1 ]
Forest, Fabien [1 ]
Froudarakis, Marios [2 ]
Casteillo, Francois [1 ]
Dumollard, Jean Marc [1 ]
Prades, Jean Michel [3 ]
Peoc'h, Michel [1 ]
机构
[1] Univ Hosp St Etienne, North Hosp, Dept Pathol, F-42055 St Etienne 2, France
[2] Univ Hosp St Etienne, North Hosp, Dept Pneumonol, F-42055 St Etienne 2, France
[3] Univ Hosp St Etienne, North Hosp, Dept Head & Neck Surg, F-42055 St Etienne 2, France
关键词
Immunohistochemistry; prognosis; histology; squamous cell carcinoma; HPV; smoking; HUMAN-PAPILLOMAVIRUS; SURVIVAL; OROPHARYNGEAL; CANCER; MUTATION;
D O I
10.1016/j.pathol.2016.01.005
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Different histopathology and prognosis characterise the human papillomavirus (HPV)-related oropharyngeal tumours, but squamous cell carcinomas (SCC) of other localisations have not been exhaustively studied. Tissues from 120 patients with a head and neck SCC were studied for the expression of p16 and p53, and the Brandwein-Gensler (BG) histological risk assessment model. p16 positivity and p53 normal expression were significantly correlated with non-smoking, an earlier T stage and a non-keratinising morphology. The BG risk score was not associated with p16 or p53 expression; p16 expression was associated with a lymphocytic T-cytotoxic response. BG risk score was significantly correlated with overall survival and progression-free survival, while neither p16 nor p53 expression were associated with prognosis. p16 and p53 expression are associated with the histological subtype and the T stage even in non-oropharyngeal-restricted tumours. The BG risk score is not correlated with p16 or p53 and retains its power in non-site-specific SCCs.
引用
收藏
页码:341 / 348
页数:8
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