α-Amylase and Lipase Inhibitory Activity and Structural Characterization of Acacia Bark Proanthocyanidins

被引：107

作者：

Kusano, Rio ^{[1
]}

Ogawa, Sosuke ^{[2
]}

Matsuo, Yosuke ^{[1
]}

Tanaka, Takashi ^{[1
]}

Yazaki, Yoshikazu ^{[3
]}

Kouno, Isao ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Lab Nat Prod Chem, Nagasaki 8528521, Japan

[2] Mimozax Co Ltd, Hiroshima 7380034, Japan

[3] Monash Univ, Dept Chem Engn, Clayton, Vic 3800, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 02期

关键词：

TOF MASS-SPECTROMETRY; CONDENSED TANNINS; POLYFLAVONOID TANNINS; LEAVES; CONSTITUENTS; PROCYANIDINS; CELLS; TEA; GLYCOSIDES; FLAVONOIDS;

D O I：

10.1021/np100372t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bark extract of Acacia mearnsii showed strong lipase and alpha-amylase inhibition activities. Fractionation of the extract by column chromatography and subsequent C-13 NMR and MALDI-TOF-MS analysis revealed that the active substances are proanthocyanidin oligomers mainly composed of 5-deoxyflavan-3-ol units. In addition, 4'-O-methylrobinetinidol 3'-O-beta-D-glucopyranoside, fisetinidol-(4 alpha,6)-gallocatechin, and epirobinetinidol-(4 beta,8)-catechin were isolated as new compounds, and their structures were determined from spectroscopic data. Furthermore, a modified thiol degradation method using strongly acidic conditions was applied to the extract to yield three thiol degradation products dezived from robinetinidol units. This method is useful for characterizing acacia proanthocyanidins (wattle tannins).

引用

页码：119 / 128

页数：10

共 50 条

[1] Characterization of the α-Amylase Inhibitory Activity of Oligomeric Proanthocyanidins from Acacia mearnsii Bark Extract
Matsuo, Yosuke
Kusano, Rie
Ogawa, Sosuke
Yazaki, Yoshikazu
Tanaka, Takashi
[J]. NATURAL PRODUCT COMMUNICATIONS, 2016, 11 (12) : 1851 - 1854
[2] Inhibition of tyrosinase by cherimoya pericarp proanthocyanidins: Structural characterization, inhibitory activity and mechanism
Chai, Wei-Ming
Lin, Mei-Zhen
Wang, Ying-Xia
Xu, Kai-Li
Huang, Wen-Yang
Pan, Dan-Dan
Zou, Zheng-Rong
Peng, Yi-Yuan
[J]. FOOD RESEARCH INTERNATIONAL, 2017, 100 : 731 - 739
[3] Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii
Chen, X.
Xiong, J.
He, Q.
Wang, F.
[J]. JOURNAL OF CHEMISTRY, 2019, 2019
[4] Characterization of proanthocyanidins from the bark of Bassia longifolia
Buerkel, P.
Rajbhandari, M.
Juergenliemk, G.
[J]. PLANTA MEDICA, 2022, 88 (15) : 1478 - 1479
[5] Inhibitory effects of bark proanthocyanidins on the activities of glucosyltransferases of Streptococcus sobrinus
Mitsunaga, T
Abe, I
Kontani, M
Ono, H
Tanaka, T
[J]. JOURNAL OF WOOD CHEMISTRY AND TECHNOLOGY, 1997, 17 (03) : 327 - 340
[6] Inhibitory effects of bark proanthocyanidins on the activities of glucosyltransferases of Streptococcus sobrinus
Mitsunaga, Tohru
Abe, Isao
Kontani, Masanori
Ono, Hiroyuki
Tanaka, Takaharu
[J]. Marcel Dekker Inc, New York, NY, United States (17):
[7] Structure, antioxidant and α-amylase inhibitory activities of longan pericarp proanthocyanidins
Fu, Caili
Yang, Xuena
Lai, Shaojuan
Liu, Chang
Huang, Shangrong
Yang, Hongshun
[J]. JOURNAL OF FUNCTIONAL FOODS, 2015, 14 : 23 - 32
[8] Significance of storage study on α-amylase inhibitory activity, α-glucosidase inhibitory activity and pancreatic lipase inhibitory activity of fermented milk-based beverage
Kinariwala, Dhvany
Hati, Subrota
[J]. INDIAN JOURNAL OF DAIRY SCIENCE, 2020, 73 (04): : 335 - 342
[9] Inhibitory effect of Myrica bark on lipase activity in mouse plasma and gastrointestinal tract
Kobayashi, Kyoko
Ihara, Satomi
Kobata, Ayumi
Itoh, Kana
Kusunoki, Nae
Yoshizaki, Fumihiko
[J]. JOURNAL OF MEDICINAL FOOD, 2008, 11 (02) : 289 - 293
[10] Anti-caries activity of bark proanthocyanidins
Mitsunaga, T
[J]. PLANT POLYPHENOLS 2: CHEMISTRY, BIOLOGY, PHARMACOLOGY, ECOLOGY, 2000, 66 : 555 - 573

← 1 2 3 4 5 →