Fluconazole in combination with flucytosine in the treatment of fluconazole-resistant Candida infections

被引：16
|
作者：
Girmenia, C
Venditti, M
Martino, P
机构：
[1] Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Dipartimento Med Clin, Rome, Italy
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2003年 / 46卷 / 03期
关键词：
D O I：
10.1016/S0732-8893(03)00064-6
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Two patients with renal failure and fluconazole resistant but flucytosine susceptible Candida deep infection were successfully treated with the combination of the two drugs. In vitro susceptibility, determined by microdilution and time-kill methods, and fungostatic activity of the serum showed an additive interaction of fluconazole and flucytosine. In the event of infections by Candida isolates resistant to fluconazole but susceptible to 5-fluorocytosine, the combination of these drugs may be a possible therapeutic choice. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：227 / 231
页数：5
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